Some photographers are very proud to say they use manual exposure mode for tuning their camera. When shooting in a studio with flashes, yes, I agree... ISO set to minimum to maximize the image quality, speed set to synchro flash to neutralize ambiant light and aperture set accordingly to the quantity of flash light: this is the common way. But, in a common context, why using manual exposure?
Let's remind the basics of tuning a camera exposure thanks to a light cell embedded into the camera that measures the average (weighted average, multi-zone,...) luminance L in cd/m2 (candela per square meter). As said in a previous post, tuning a camera to get a correct exposure amounts to move in a 3+1 dimensional space with one contraint. If each dimension is represented by a variable: N the f number (1:5.6 → 5.6) defining the aperture, S the arithmetic sensitivity in ISO and t the exposure time in seconds, then 1 variable is dependent on the 2 others. As a reminder, I say 3+1 and not 3 dimensions, because an extra-light quantity, brought for instance by light flashes, can be used to modify the ambiant average luminance. But for now, let's forget the extra-light.
Let's write the constraint as a relation between the 3 mentioned variables.



The higher the aperture (lower f number), the shallower is the crisp area. The lower the ISO sensitivity (less amplification of the sensor signals), the less grainy is the picture. The smaller the exposure time, the more motion can be frozen on a photograph. It means that all the possible solutions of the 3-dimensional space, with one constraint, are not equivalent.
In most modern cameras, automatisms make it easy to evolve in the space of possible solutions corresponding to a measured luminance. In case the luminance is not properly measured, there is an exposure compensation to fix it. ISO amplification mechanism can be fixed with an auto-ISO mechanism that set the ISO amplification such as the minimum time exposure is fixed to avoid blurred pictures due to camera shaking, given an aperture, in case of aperture priority. Therefore, the exposure time t and the ISO amplification are directly resulting from the aperture. The exposure time can also be set. In that case, the aperture is set according to a rule to avoid too much ISO amplification.
Whatever the context is, after correcting the measured average luminance, the solutions are lying in a contrained 2-dimensional space. Therefore, manual exposure that let the 3 variables independent is not meaningful: it's a kind of snobbery.
To make good photographs, it's much better to make it easy with the camera tuning to direct the whole attention to the image capture: subject, framing,...
As a final thought, I would add that raw shooting accept much more tolerance in irrelevant average luminance measurement... It's going in the same direction than automatisms. Personnally, I recommend to control the aperture because it has a strong impact on the photograph, and auto-ISO that adjusts ISO amplification in order to avoid blurred photographs if possible. If needed, the rule used by auto-ISO mechanism can be forced. Shooting should be as easy as possible to let the photographer focusing on making great pictures. Old time photographers with manual exposure and even without embedded cell were compensating this complexity by tuning their camera before a interesting situation occurs. It's maybe a justification for using manual exposure: when tuning the camera in advance...